Mutation Characteristics of the Gene that Codes for CAK

Of the genes that code for CAK, wee1, and cdc25, which would you expect, when mutated, to stop a cell from continuing to divide? Which would you expect, when mutated, to cause the cell to proliferate in an uncontrolled manner?

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...ffects on Cdk:

CAK (Cdk activating kinase): phosphorylates Cdk at T161. Thus it is required for Cdk activation.

wee1: phosphorylates Cdk at T14 and Y15. Thus it acts as an inhibitor of Cdk activity.

cdc25: dephosphorylates T14 and Y15. Thus it acts in opposition to wee1 to re-activate Cdk when the cell size checkpoint is met.

Therefore, mutations in the three genes will give phenotypes as follows:

Loss of function mutations ...