Mutation Characteristics of the Gene that Codes for CAK
Of the genes that code for CAK, wee1, and cdc25, which would you expect, when mutated, to stop a cell from continuing to divide? Which would you expect, when mutated, to cause the cell to proliferate in an uncontrolled manner?© SolutionLibrary Inc. solutionlibary.com 9836dcf9d7 https://solutionlibrary.com/biology/genetics/mutation-characteristics-of-the-gene-that-codes-for-cak-2ha
...ffects on Cdk:
CAK (Cdk activating kinase): phosphorylates Cdk at T161. Thus it is required for Cdk activation.
wee1: phosphorylates Cdk at T14 and Y15. Thus it acts as an inhibitor of Cdk activity.
cdc25: dephosphorylates T14 and Y15. Thus it acts in opposition to wee1 to re-activate Cdk when the cell size checkpoint is met.
Therefore, mutations in the three genes will give phenotypes as follows:
Loss of function mutations ...