Cellular Secondary Messengers: Calcium, IP3 and cAMP
Calcium (Ca), IP3, and cAMP are very different second messengers. In what ways are their mechanisms of action similar? In what ways are they different?© SolutionLibrary Inc. solutionlibary.com 9836dcf9d7 https://solutionlibrary.com/biology/human-biology/cellular-secondary-messengers-calcium-ip3-and-camp-1vp
...ia conversion of ATP by adenylate cyclase (AC). The newly formed cAMP will elevate downstream kinase activity such as that of PKA which phosphorylates many essential target molecules. If however the α-subunit acts through Phospholipase C (PLC) two effectors will be seen in the formation of IP3 and diacylglyceral (DAG) from the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2). DAG will elevate kinase activity but in the form of PKC. IP3 release from its association with the plasma membrane bound fatty acids/glycerol will act on the receptors of the sarcoendoplasmic reticulum to elicit a large calcium release which will also augment or ...